2020 Nov 18;151:16-19. doi: 10.1016/j.lungcan.2020.11.007. Osimertinib or platinum–pemetrexed in EGFR T790M–positive lung cancer. HHS Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. J Clin Oncol. Clin Lung Cancer. Keep up with the growing number of precision medicines targeting specific mutations in lung cancer. A study known as IPASS illustrates how treatment response can vary by EGFR mutation status. Tetsu O, Hangauer MJ, Phuchareon J, Eisele DW, McCormick F. BACKGROUND: The discovery of mutations in epidermal growth factor receptor (EGFR) has dramatically changed the treatment of patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths worldwide. Compared with traditional platinum-based combination chemotherapy, EGFR TKI monotherapy has become the recommended treatment strategy and the cornerstone of combined therapy for NSCLC patients with an EGFR mutation*. The identification of EGFR as an oncogene has led to the development of anticancer therapeutics directed against EGFR (called "EGFR inhibitors"), including gefitinib, erlotinib, afatinib, brigatinib and … USA.gov. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. Tri Le 1 and David E. Gerber 1,2,3,* 1 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8852, USA; email@example.com 2 Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390-8852, USA Gilotrif was particularly beneficial to the 308 patients who had one of two common types of EGFR mutations (deletion 19 or L858R) that account of approximately 90 percent of all EGFR mutations. Haematologica. Planchard D, Loriot Y, André F, Gobert A, Auger N, Lacroix L, Soria JC. The FLAURA trial established osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), as a viable first-line therapy in non-small cell lung cancer (NSCLC) with sensitizing EGFR mutations, namely exon 19 deletion and L… In order to overcome the resistance to the C797S mutation which occurs in 32% of patients fourth-generation EGFR-TKIs are being developed. (35). Tyrosine kinase inhibitors for solid tumors in the past 20 years (2001-2020). Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Dysregulated Pyrimidine Biosynthesis Contributes to 5-FU Resistance in SCLC Patient-Derived Organoids but Response to a Novel Polymeric Fluoropyrimidine, CF10. At the time of data analysis, median overall survival and progression-free survival was greater in the group of patients treated with afatinib than the group treated with Tarceva. It is a relatively new approach to lung cancer treatment. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Background. (3) To overcome this resistance third-generation EGFR-mutant selective TKIs were developed. J Clin Oncol. Presented at ELCC 2015, abstract number LBA2 PR.. Serious side effects were also less common in the Tarceva group. The epidermal growth factor receptor (EGFR) refers to a pathway in cells that is involved in cellular growth and spread. Liquid biopsies improve access to treatment options for many cancers and may replacing tissue tests & diagnostic imaging. NIH The trial included approximately 800 patients and included over 20 countries. Lung cancer caused by EGFR mutations is often treated with a group of chemotherapy drugs called EGFR tyrosine kinase inhibitors (TKIs). Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. The researchers concluded that Gilotrif appears to be an effective treatment option for patients with advanced squamous cell lung cancer. The effect of the EGFR M766Q mutation on sensitivity/resistance to different EGFR TKIs was evaluated preclinically and confirmed. Accessed June 1, 2020. 2009;462:1070–4. 2016;11:e121–3. Tagrisso provided a significant progression-free survival benefit in Asian patients with EGFR-mutated NSCLC. Tetsu O, Hangauer MJ, Phuchareon J, Eisele DW, McCormick F. BACKGROUND: The discovery of mutations in epidermal growth factor receptor (EGFR) has dramatically changed the treatment of patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer … Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, Patnaik A, Aggarwal C, Gubens M, Horn L, Carcereny E, Ahn MJ, Felip E, et al. N. Engl. 2015;372:1689–99. Curr Opin Oncol. 2010;28:357–60. 2015;373:1627–39. J Clin Oncol 20:3815-3825, 2002. 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